What symptom commonly follows the initial presentation of fever and cold symptoms in Fifth disease?

Fifth disease, also known as erythema infectiosum, is primarily caused by parvovirus B19. The typical clinical presentation begins with mild, flu-like symptoms such as fever, headache, and cold-like symptoms. Following this initial phase, a distinctive symptom appears: bright red cheeks, often referred to as "slapped cheek" appearance, accompanied by a lacy, reticular rash that may extend to the body and limbs.

This characteristic rash develops after the initial symptoms, typically several days to weeks later, indicating the body's response to the virus. The rash tends to be more pronounced in children, and it can cause confusion with other viral exanthems due to its appearance. However, the combination of bright red cheeks and the lacy rash is particularly indicative of Fifth disease, differentiating it from other viral infections.

Other symptoms such as blister-like sores or pus-filled blisters are not associated with Fifth disease and pertain to other conditions rather than this specific viral infection.