What does the Symogi effect describe?

The Symogi effect describes the phenomenon where hypoglycemia, or low blood sugar levels, leads to subsequent hyperglycemia, or high blood sugar levels. This effect typically occurs in individuals with diabetes who may experience low blood sugar during the night or in response to an insulin dose. The body reacts to the low glucose levels by releasing hormones such as glucagon and epinephrine, which stimulate the liver to produce glucose through gluconeogenesis and glycogenolysis. As a result, this can lead to a rebound effect, causing elevated blood sugar levels after the initial hypoglycemic episode.

This understanding is critical for managing diabetes effectively, as individuals may misinterpret the elevated blood sugar following a hypoglycemic event as a need for increased insulin or diabetes medications, potentially leading to a dangerous cycle of blood sugar fluctuations. By recognizing this effect, individuals can better tailor their treatment plans to prevent both hypoglycemia and the resulting rebound hyperglycemia.